The gp120 of the transmitted/founder HIV-1 strain 1059 (Clade B).
HIV-1 envelope glycoproteins (Envs) mediate HIV-1 entry and they are assembled into a trimer on the viral particle; each unit of the trimer contains the surface gp120 protein non-covalently associated with the transmembrane gp41 protein.
HIV-1 1059 was identified as one the strains that can cross the mucosal bottleneck and establish HIV-1 infection in vivo. HIV-1 1059 Envs contain high frequency of common T cell epitopes and the soluble form SOSIP is currently used in clinical trials in humans.
The gp120 of the transmitted/founder HIV-1 strain 1059 (Clade B).
HIV-1 envelope glycoproteins (Envs) mediate HIV-1 entry and they are assembled into a trimer on the viral particle; each unit of the trimer contains the surface gp120 protein non-covalently associated with the transmembrane gp41 protein.
HIV-1 1059 was identified as one the strains that can cross the mucosal bottleneck and establish HIV-1 infection in vivo. HIV-1 1059 Envs contain high frequency of common T cell epitopes and the soluble form SOSIP is currently used in clinical trials in humans.