Synthetic biology for bioengineering the next-generation biomolecules
Developing synthetic antibodies to bind difficult-to-target key molecules involved in diverse diseases
Bioengineering T cell receptor mimetics to target virus-infected and cancer cells
Reprogramming natural killer and T cells by advanced genetic circuits
Building mRNA vaccines to deliver stabilized immunogens and improve vaccine presentation to the immune system
MHC-Class I complex expression on T cells (green)
Technology development
Detection of human T cells presenting an HIV-1 peptide on their MHC-class I complexes (red). Recognition is mediated by synthetic virus-like particles that display a bioengineered antibody (ScFv)