Synthetic immunology and virology
Bioengineering the next-generation tools, molecular biosensors, therapeutics, and vaccines.
Synthetic penetrating antibodies
Some antigens, such as viral and cancer proteins, have evolved mechanisms to mask their target site and evade the immune system.
SyntIV develops antibodies with extended antigen recognition site to recognize occluded target sites by building and screening unique focused synthetic antibody libraries.
Bioengineering T cell receptor specificity
SyntIV is using direceted evolution to develop high affinity antibodies that mimic T cell receptor (TCR) and recognize the HLA presenting specific peptides (viral or cancer-derived) with high affinity and specificity.
These antibodies can detect and mediate elimination of virus-infected and cancer cells either as soluble antibodies or reformatted as chimeric antigen receptors on T and NK cells.
Ratnapriya et al. Cell Reports 2021
Building genetic circuits
Cells contain complex network of genetic circuits with negative and positive feedback loops to control biological processes and ensure homeostasis.
SyntIV uses synthetic biology to build vectors to control and manipulate cellular processes and use them to increase protein production, generate improved cell lines with specific activity, and reprogram cells for specific function
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Human proteins
Viral proteins
Antibodies
Products are validated (published results), carry human post-translational modifications, and are highly purified
